Annona triloba, Asimina, Asimina triloba, Asiminier, Asiminier Trilobé, Asiminier de Virginie, Banane du Pauvre Homme, Custard Apple, Dog-Banana, Papaye Américaine, Papaye American, Papaye Nordique, Pawpaw, Paw Paw.
American pawpaw is a plant. The bark, leaf, and seed are used to make medicine.
In homeopathy, American pawpaw is used for treating fever, vomiting, and pain and swelling (inflammation) of the mouth and throat. Homeopathy is an alternative treatment method that uses extreme dilutions of medicines.
How does it work?
American pawpaw has chemicals that might have activity against certain lung and breast cancers.
QUESTION
Next to red peppers, you can get the most vitamin C from ________________. See AnswerInsufficient Evidence to Rate Effectiveness for...
- Head lice. Early research suggests that applying a shampoo that contains American pawpaw, thymol, and tea tree oil to the head up to three times over 16 days can eliminate lice in adults and children.
- Fever.
- Vomiting.
- Swelling of the mouth and throat.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
American pawpaw is POSSIBLY SAFE when applied to the skin by adults and children, short-term. A shampoo containing American pawpaw extract, thymol, and tea tree oil has been applied safely to the head up to three times over 16 days. But in some people, American pawpaw extract might cause a red, itchy rash when applied to the skin.
There isn't enough information to know if American pawpaw fruit or extract are safe when taken by mouth. Eating American pawpaw fruit might cause side effects such as hives, nausea, vomiting, headache, or faintness in some people. When taken by mouth, American pawpaw extract might cause vomiting.
It can cause some side effects such as nausea, rash, and itching.
SLIDESHOW
Vitamin D Deficiency: How Much Vitamin D Is Enough? See SlideshowThe appropriate dose of American pawpaw depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for American pawpaw. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Ahammadsahib, K. I., Hollingworth, R. M., McGovren, J. P., Hui, Y. H., and McLaughlin, J. L. Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin. Life Sci 1993;53(14):1113-1120. View abstract.
Alali, F. Q., Liu, X. X., and McLaughlin, J. L. Annonaceous acetogenins: recent progress. J Nat Prod 1999;62(3):504-540. View abstract.
Haribal, M. and Feeny, P. Combined roles of contact stimulant and deterrents in assessment of host-plant quality by ovipositing zebra swallowtail butterflies. J Chem Ecol. 2003;29(3):653-670. View abstract.
Kim, E. J., Suh, K. M., Kim, D. H., Jung, E. J., Seo, C. S., Son, J. K., Woo, M. H., and McLaughlin, J. L. Asimitrin and 4-hydroxytrilobin, new bioactive annonaceous acetogenins from the seeds of Asimina triloba possessing a bis-tetrahydrofuran ring. J Nat Prod 2005;68(2):194-197. View abstract.
Kim, E. J., Tian, F., and Woo, M. H. Asitrocin, (2,4)-cis- and trans-asitrocinones: novel bioactive mono-tetrahydrofuran acetogenins from Asimina triloba seeds. J.Nat.Prod. 2000;63(11):1503-1506. View abstract.
Magness, JR., Markle, GM., and Compton, CC. Food and feed crops of the United States. Interregional Research Project IR-4 1971;IR Bul. 1:Bul. 828.
Martin, J. M., Madigosky, S. R., Gu, Z. M., Zhou, D., Wu, J., and McLaughlin, J. L. Chemical defense in the zebra swallowtail butterfly, Eurytides marcellus, involving annonaceous acetogenins. J Nat Prod 1999;62(1):2-4. View abstract.
McCage, C. M., Ward, S. M., Paling, C. A., Fisher, D. A., Flynn, P. J., and McLaughlin, J. L. Development of a paw paw herbal shampoo for the removal of head lice. Phytomedicine 2002;9(8):743-748. View abstract.
McLaughlin, JL., Zeng, L., Oberlies, NH., Alfonso, D., Johnson, HA., and Cummings, BA. Annonaceous acetogenins as new natural pesticide: Recent progress In: Phytochemicals for pest control. 1997;119-133.
Rupprecht, J. K., Hui, Y. H., and McLaughlin, J. L. Annonaceous acetogenins: a review. J Nat Prod 1990;53(2):237-278. View abstract.
Rupprecht, JK., Chang, CJ., Cassady, JM., McLaughlin, JL., Mikolajczak, KL., and Weisleder, D. Asimicin, a new cytotoxic and pesticidal acetogenin from the pawpaw, Asimina triloba (Annonaceae). Heterocycles 1986;24:1197-1201.
Tomita, M. and Kozuka, M. [Alkaloids of Asmina triloba Dunal.]. Yakugaku Zasshi 1965;85:77-82. View abstract.
Woo, M. H., Cho, K. Y., Zhang, Y., Zeng, L., Gu, Z. M., and McLaughlin, J. L. Asimilobin and cis- and trans-murisolinones, novel bioactive Annonaceous acetogenins from the seeds of Asimina triloba. J.Nat.Prod. 1995;58(10):1533-1542. View abstract.
Woo, M. H., Chung, S. O., and Kim, D. H. Asitrilobins C and D: two new cytotoxic mono-tetrahydrofuran annonaceous acetogenins from Asimina triloba seeds. Bioorg.Med.Chem. 2000;8(1):285-290. View abstract.
Woo, M. H., Kim, D. H., and McLaughlin, J. L. Asitrilobins A and B: cytotoxic mono-THF annonaceous acetogenins from the seeds of Asimina triloba. Phytochemistry 1999;50(6):1033-1040. View abstract.
Wood, R. and Peterson, S. Lipids of the pawpaw fruit: Asimina triloba. Lipids 1999;34(10):1099-1106. View abstract.
Ye, Q., He, K., Oberlies, N. H., Zeng, L., Shi, G., Evert, D., and McLaughlin, J. L. Longimicins A-D: novel bioactive acetogenins from Asimina longifolia (annonaceae) and structure-activity relationships of asimicin type of annonaceous acetogenins. J Med Chem 4-26-1996;39(9):1790-1796. View abstract.
Zhao, G. X., Chao, J. F., Zeng, L., and McLaughlin, J. L. (2,4-cis)-asimicinone and (2,4-trans)-asimicinone: two novel bioactive ketolactone acetogenins from Asimina triloba (Annonaceae). Nat.Toxins. 1996;4(3):128-134. View abstract.
Zhao, G. X., Chao, J. F., Zeng, L., Rieser, M. J., and McLaughlin, J. L. The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba. Bioorg.Med.Chem. 1996;4(1):25-32. View abstract.
Zhao, G. X., Rieser, M. J., Hui, Y. H., Miesbauer, L. R., Smith, D. L., and McLaughlin, J. L. Biologically active acetogenins from stem bark of Asimina triloba. Phytochemistry 1993;33(5):1065-1073. View abstract.
Zhao, G., Hui, Y., Rupprecht, J. K., McLaughlin, J. L., and Wood, K. V. Additional bioactive compounds and trilobacin, a novel highly cytotoxic acetogenin, from the bark of Asimina triloba. J.Nat.Prod. 1992;55(3):347-356. View abstract.
A novel mechanism for the control of clinical cancer: inhibition of the production of adenosine triphosphate (ATP) with a standardized extract of paw paw (Asimina triloba, Annonaceae) (Unpublished). 2001.
Avalos J, Rupprecht JK, McLaughlin JL, et al. Guinea pig maximization test of the bark extract from pawpaw, Asimina triloba (Annonaceae). Contact Dermatitis 1993;29:33-5. View abstract.
Barber MA. Poisoning due to the papaw (Asimina triloba). JAMA. 1905;XLV(27):2013-2014.
He K, Zhao GX, Shi G, et al. Additional bioactive annonaceous acetogenins from Asminia triloba (Annonaceae). Bioorg Med Chem 1997;5:501-6. View abstract.
McLaughlin JL. Paw paw and cancer: Annonaceous acetogenins from discover to commercial products. J Nat Prod. 2008;71:1311-1321. View abstract.
Ratnayake S, Rupprecht JK, Potter WM, McLaughlin JL. Evaluation of various parts of the paw paw tree, Asmina triloba (Annonaceae), as commercial sources for the pesticidal annonaceous acetogenins. J Econ Entomol 1992;85:2353-6. View abstract.
Zhao GX, Miesbauer LR, Smith DL, et al. Asimin, asimininacin, and asiminecin: novel highly cytotoxic asimicin isomers from Asiminia triloba. J Med Chem 1994;37:1971-6. View abstract.