Extrait de Moule, GLM, Green Lipped Mussel, Green Shell Mussel, Mejillón Verde de Nueva Zealandia, Moule à Coquille Verte, Moule à Coquille Verte de Nouvelle-Zélande, Moule aux Lèvres Verte de Nouvelle-Zélande, Moule Vert-Labiée de Nouvelle-Zélande, Moule Verte de Nouvelle-Zélande, Mussel Extract, New Zealand Green Lipped Sea Mussel, New Zealand Green Mollusk, NZGLM, Perna canaliculus, Sea Mussel, Seatone.
New Zealand green-lipped mussel is a shellfish. People use it to make medicine. As a medicine, it is available in freeze-dried, ground, and capsule form.
New Zealand green-lipped mussel is used for rheumatoid arthritis, osteoarthritis, and asthma.
How does it work?
New Zealand green-lipped mussel might contain chemicals that help decrease inflammation.
SLIDESHOW
Vitamin D Deficiency: How Much Vitamin D Is Enough? See SlideshowInsufficient Evidence to Rate Effectiveness for...
- Asthma. Developing research suggests that a particular extract of New Zealand green-lipped mussel (Lyprinol, Pharmalink) decreases daytime wheezing and improves breathing in some people with asthma.
- Osteoarthritis. Early research suggests that taking New Zealand green-lipped mussel extract by mouth reduces symptoms of osteoarthritis, including pain and stiffness. However, other research shows little or no benefit. Most studies have used a specific extract of New Zealand green-lipped mussel (Seatone, MacFarland Laboratories), although some studies used another specific extract of New Zealand green-lipped mussels (Lyprinol, Pharmalink).
- Rheumatoid arthritis (RA). Some early research suggests that taking a specific extract of New Zealand green-lipped mussel (Seatone, McFarlane Laboratories) by mouth reduces symptoms of RA, including pain and stiffness. However, other research shows no benefit.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
New Zealand green-lipped mussel is POSSIBLY SAFE for most people when taken by mouth. It can cause some side effects such as diarrhea, nausea, and intestinal gas. In rare cases, it might cause liver problems.
QUESTION
Next to red peppers, you can get the most vitamin C from ________________. See AnswerThere is not enough reliable information about the safety of taking New Zealand green-lipped mussel if you are breast-feeding. Stay on the safe side and avoid use.
The appropriate dose of New Zealand green-lipped mussel depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for New Zealand green-lipped mussel. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Cho, S. H., Jung, Y. B., Seong, S. C., Park, H. B., Byun, K. Y., Lee, D. C., Song, E. K., and Son, J. H. Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial. Eur Ann Allergy Clin Immunol 2003;35(6):212-216. View abstract.
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Lau, S., Chiu, P. K., Chu, E. M. Y., Cheng, I. Y. W., Tang, W. M., Man, R. Y. K., and Halpern, G. M. Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study. Progress in Nutrition 2004;61(17):17-31.
Lawson, B. R., Belkowski, S. M., Whitesides, J. F., Davis, P., and Lawson, J. W. Immunomodulation of murine collagen-induced arthritis by N, N-dimethylglycine and a preparation of Perna canaliculus. BMC.Complement Altern Med 2007;7:20. View abstract.
MacKenzie, L., Holland, P., McNabb, P., Beuzenberg, V., Selwood, A., and Suzuki, T. Complex toxin profiles in phytoplankton and Greenshell mussels (Perna canaliculus), revealed by LC-MS/MS analysis. Toxicon 2002;40(9):1321-1330. View abstract.
Mani, S. and Lawson, J. W. In vitro modulation of inflammatory cytokine and IgG levels by extracts of Perna canaliculus. BMC.Complement Altern Med 2006;6:1. View abstract.
McPhee, S., Hodges, L. D., Wright, P. F., Wynne, P. M., Kalafatis, N., Harney, D. W., and Macrides, T. A. Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B Biochem Mol.Biol 2007;146(3):346-356. View abstract.
Miles, C. O., Wilkins, A. L., Munday, R., Dines, M. H., Hawkes, A. D., Briggs, L. R., Sandvik, M., Jensen, D. J., Cooney, J. M., Holland, P. T., Quilliam, M. A., MacKenzie, A. L., Beuzenberg, V., and Towers, N. R. Isolation of pectenotoxin-2 from Dinophysis acuta and its conversion to pectenotoxin-2 seco acid, and preliminary assessment of their acute toxicities. Toxicon 2004;43(1):1-9. View abstract.
Morohashi, A., Satake, M., Naoki, H., Kaspar, H. F., Oshima, Y., and Yasumoto, T. Brevetoxin B4 isolated from greenshell mussels Perna canaliculus, the major toxin involved in neurotoxic shellfish poisoning in New Zealand. Nat Toxins. 1999;7(2):45-48. View abstract.
New Zealand green-lipped mussel extract (Seatone) and rheumatoid arthritis. N Z Med J 5-27-1981;93(684):343. View abstract.
Pollard, B., Guilford, W. G., Ankenbauer-Perkins, K. L., and Hedderley, D. Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease. N Z Vet.J 2006;54(3):114-118. View abstract.
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Singh, M., Hodges, L. D., Wright, P. F., Cheah, D. M., Wynne, P. M., Kalafatis, N., and Macrides, T. A. The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats. Comp Biochem Physiol B Biochem Mol.Biol 2008;149(2):251-258. View abstract.
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Torres, D. M., Tooley, K. L., Butler, R. N., Smith, C. L., Geier, M. S., and Howarth, G. S. Lyprinol only partially improves indicators of small intestinal integrity in a rat model of 5-fluorouracil-induced mucositis. Cancer Biol Ther 2008;7(2):295-302. View abstract.
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Whitehouse, M. W., Macrides, T. A., Kalafatis, N., Betts, W. H., Haynes, D. R., and Broadbent, J. Anti-inflammatory activity of a lipid fraction (lyprinol) from the NZ green-lipped mussel. Inflammopharmacology. 1997;5(3):237-246. View abstract.
Wolyniak, C. J., Brenna, T., Murphy, K. J., and Sinclair, A. J. Gas chromatography-chemical ionization-mass spectrometric fatty acid analysis of a commercial supercritical carbon dioxide lipid extract from New Zealand green-lipped mussel (Perna canaliculus). Lipids 2005;40(4):355-360. View abstract.
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Gibson SL. The effect of a lipid extract of the New Zealand green-lipped mussel in three cases of arthritis. J Altern Complement Med 2000;6:351-4. View abstract.
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Miller TE, Dodd J, Ormrod DJ, Geddes R. Anti-inflammatory activity of glycogen extracted from Perna canaliculus (NZ green-lipped mussel). Agents Actions 1993;38 Spec No:C139-42. View abstract.
Murphy KJ, Mann NJ, Sinclair AJ. Fatty acid and sterol composition of frozen and freeze-dried New Zealand Green Lipped Mussel (Perna canaliculus) from three sites in New Zealand. Asia Pac J Clin Nutr 2003;12:50-60. View abstract.
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