Agracejo, Barberry, Berberidis Cortex, Berberidis Fructus, Berberidis Radicis Cortex, Berberidis Radix, Berbéris Commun, Berberis jacquinii, Berberis sanguinea, Berbéris Vulgaire, Berberis vulgaris, Berberitze, Berberry, Berbis, Common Barberry, Épine-Vinette, Espino Cambrón, Jaundice Berry, Mountain Grape, Oregon Grape, Pipperidge, Piprage, Sauerdorn, Sow Berry, Vinettier.
European barberry is an herb. The fruit, bark, and roots are used to make medicine.
The fruit of European barberry is used for kidney, urinary tract, and gastrointestinal (GI) tract discomforts such as heartburn, stomach cramps, constipation, lack of appetite, liver and spleen disease; for bronchial and lung discomforts; for spasms; to increase circulation; to boost the immune system; and as a supplemental source of vitamin C.
The bark, root, and root bark of European barberry are also used for disorders of the GI tract, liver, gallbladder, kidney and urinary tract, respiratory tract, and heart and circulatory system; to reduce fever; as a "blood purifier;" and for narcotic withdrawal.
European barberry root bark is also used for liver problems, gallbladder disease, jaundice, spleen disorders, diarrhea, indigestion, hemorrhoids, kidney and urinary tract diseases, gout, joint pain (rheumatism), arthritis, mid- and low-back pain, malaria, and a parasitic infection called leishmaniasis.
In foods, European barberry fruit is used in making jam, jellies, and wine.
In manufacturing, the fruit syrup is used for masking tastes in medicines.
How does it work?
European barberry contains chemicals that might cause stronger heartbeat. It also might help fight inflammation.
QUESTION
Next to red peppers, you can get the most vitamin C from ________________. See AnswerInsufficient Evidence to Rate Effectiveness for...
- Dental plaque. Early research suggests that brushing teeth with a European barberry extract gel containing 1% berberine for 3 weeks reduces dental plaque. The effects appear to be similar to the anti-plaque effects of a commercial toothpaste (Colgate).
- Diabetes. Early research suggests that taking European barberry by mouth for 8 weeks does not improve blood sugar control in people with type 2 diabetes.
- Gum swelling (gingivitis). Early research suggests that brushing teeth with a European barberry extract gel containing 1% berberine for 3 weeks reduces gingivitis.
- Kidney problems.
- Bladder problems.
- Heartburn.
- Stomach cramps.
- Constipation.
- Diarrhea.
- Liver problems.
- Spleen problems.
- Lung problems.
- Heart and circulation problems.
- Fever.
- Gout.
- Arthritis.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
The fruit of European barberry is LIKELY SAFE when consumed in food amounts. There is not enough information to know if European barberry is safe in medicinal amounts.
Special Precautions & Warnings:
Children: European barberry is LIKELY UNSAFE for newborn infants when taken by mouth. It contains a chemical called berberine, which can cause brain damage, especially in premature babies who are jaundiced. Jaundice is a condition caused by too much bilirubin in the baby's system. Bilirubin is produced by the normal breakdown of red blood cells. Jaundice makes the skin and eyes of affected infants look yellow. Don't expose children to European barberry.Pregnancy and breast-feeding: Don't use European barberry by mouth if you are pregnant or breast-feeding. It is LIKELY UNSAFE for your baby. The berberine in European barberry can pass from a mother's body into her unborn child through the placenta. Brain damage has developed in newborns exposed to berberine. Similarly, berberine, as well as other harmful chemicals in European barberry, can be transferred to an infant through breast milk, and might cause brain damage.
Bleeding disorder: European barberry contains a chemical called berberine. Berberine might slow blood clotting and increase the risk of bleeding. In theory, European barberry might make bleeding disorders worse.
Diabetes: European barberry contains a chemical called berberine. Berberine might lower blood sugar levels. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use European barberry in amounts larger than the amounts normally found in food.
Low blood pressure: European barberry contains a chemical called berberine. Berberine might lower blood pressure. In theory, taking European barberry might make blood pressure become too low in people with low blood pressure.
Surgery: European barberry contains a chemical called berberine. There is concern that berberine from European barberry might prolong bleeding, slow down the nervous system, and interfere with blood sugar control during and after surgery. Stop taking European barberry at least 2 weeks before a scheduled surgery.
SLIDESHOW
Vitamin D Deficiency: How Much Vitamin D Is Enough? See SlideshowCyclosporine (Neoral, Sandimmune)Interaction Rating: Major Do not take this combination.
The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. European barberry might decrease how fast the body breaks down cyclosporine (Neoral, Sandimmune). This might cause there to be too much cyclosporine (Neoral, Sandimmune) in the body and potentially cause side effects.
Drying medications (Anticholinergic drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
European barberry might increase levels of certain chemicals in the body that work in the brain, heart, and elsewhere. Some drying medications called "anticholinergic drugs" can also affect these same chemicals, but in a different way. These drying medications might decrease the effects of European barberry and European barberry might decrease the effects of drying medications.
Some of these drying medications include atropine, scopolamine, some medications used for allergies (antihistamines), and some medications used for depression (antidepressants).
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Some medications are changed and broken down by the liver. European barberry might decrease how quickly the liver breaks down some medications. Taking European barberry along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking European barberry, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include cyclosporin (Neoral, Sandimmune), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others.
Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
European barberry might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking European barberry along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications for high blood pressure (Antihypertensive drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
European barberry might decrease blood pressure in some people. Taking European barberry along with medications used for lowering high blood pressure might cause your blood pressure to go too low. Do not take too much European barberry if you are taking medications for high blood pressure.
Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
European barberry might slow blood clotting. Taking European barberry along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Sedative medications (CNS depressants)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
European barberry might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking European barberry along with sedative medications might cause too much sleepiness. Taking European barberry along with sedative medications used in surgery might cause prolonged sedation.
Some sedative medications include pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), thiopental (Pentothal), fentanyl (Duragesic, Sublimaze), morphine, propofol (Diprivan), and others.
Various medications used for glaucoma, Alzheimer's disease, and other conditions (Cholinergic drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
European barberry might increase certain chemicals in the brain, heart, and elsewhere in the body. Some medications used for glaucoma, Alzheimer's disease, and other conditions also affect these chemicals. Taking European barberry with these medications might increase the chance of side effects.
Some of these medications used for glaucoma, Alzheimer's disease, and other conditions include pilocarpine (Pilocar and others), donepezil (Aricept), tacrine (Cognex), and others.
The appropriate dose of European barberry depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for European barberry. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Akhter, M. H., Sabir, M., and Bhide, N. K. Possible mechanism of antidiarrhoeal effect of berberine. Indian J Med Res 1979;70:233-241. View abstract.
Angerhofer, C. K., Guinaudeau, H., Wongpanich, V., Pezzuto, J. M., and Cordell, G. A. Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids. J Nat Prod 1999;62(1):59-66. View abstract.
Arayne, M. S., Sultana, N., and Bahadur, S. S. The berberis story: Berberis vulgaris in therapeutics. Pak.J Pharm Sci 2007;20(1):83-92. View abstract.
Bashir, S., Gilani, A. H., Siddiqui, A. A., Pervez, S., Khan, S. R., Sarfaraz, N. J., and Shah, A. J. Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats. Phytother.Res 2010;24(8):1250-1255. View abstract.
Bhutada, P., Mundhada, Y., Bansod, K., Dixit, P., Umathe, S., and Mundhada, D. Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. Epilepsy Behav 2010;18(3):207-210. View abstract.
Cernakova, M., Kost'alova, D., Kettmann, V., Plodova, M., Toth, J., and Drimal, J. Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium. BMC.Complement Altern.Med 2-19-2002;2:2. View abstract.
Chan, M. Y. The effect of berberine on bilirubin excretion in the rat. Comp Med East West 1977;5(2):161-168. View abstract.
Chang, K. S., Gao, C., and Wang, L. C. Berberine-induced morphologic differentiation and down-regulation of c- Ki-ras2 protooncogene expression in human teratocarcinoma cells. Cancer Lett. 12-3-1990;55(2):103-108. View abstract.
Chi, C. W., Chang, Y. F., Chao, T. W., Chiang, S. H., P'eng, F. K., Lui, W. Y., and Liu, T. Y. Flowcytometric analysis of the effect of berberine on the expression of glucocorticoid receptors in human hepatoma HepG2 cells. Life Sci. 1994;54(26):2099-2107. View abstract.
Choudhry, V. P., Sabir, M., and Bhide, V. N. Berberine in giardiasis. Indian Pediatr. 1972;9(3):143-146. View abstract.
Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182.
Chung JG, Wu LT, Chang SH, and et al. Inhibitory actions of berberine on growth and arylamine N-acetyltransferase activity in strains of Helicobacter Pylori from peptic ulcer patients. International Journal of Toxicology 1999;18:35.
Ckless, K., Schlottfeldt, J. L., Pasqual, M., Moyna, P., Henriques, J. A., and Wajner, M. Inhibition of in-vitro lymphocyte transformation by the isoquinoline alkaloid berberine. J Pharm Pharmacol. 1995;47(12A):1029-1031. View abstract.
Creasey, W. A. Biochemical effects of berberine. Biochem.Pharmacol. 4-1-1979;28(7):1081-1084. View abstract.
Cui, G., Qin, X., Zhang, Y., Gong, Z., Ge, B., and Zang, Y. Q. Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. J Biol Chem 10-9-2009;284(41):28420-28429. View abstract.
Cybulska, P., Thakur, S. D., Foster, B. C., Scott, I. M., Leduc, R. I., Arnason, J. T., and Dillon, J. A. Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles. Sex Transm.Dis 2011;38(7):667-671. View abstract.
Di, D. L., Liu, Y. W., Ma, Z. G., and Jiang, S. X. [Determination of four alkaloids in Berberis plants by HPLC]. Zhongguo Zhong.Yao Za Zhi. 2003;28(12):1132-1134. View abstract.
Döpke W. Neue alkaloide aus
Dutta NK and Iyer SN. Anti-amoebic value of berberine and kurchi alkaloids. Journal of the Indian Medical Association 1968;50(8):349-354.
Ebrahimi-Mamaghani M, Arefhosseini SR, Golzar, M, Aliasgarzadeh A, and Vahed-Jabbary M. [Long-term effects of processed berberis vulgaris on some metabolic syndrome components]. Canadian Journal of Forest Research 2009;39(11):2109-2118.
Fatehi-Hassanabad, Z., Jafarzadeh, M., Tarhini, A., and Fatehi, M. The antihypertensive and vasodilator effects of aqueous extract from Berberis vulgaris fruit on hypertensive rats. Phytother Res 2005;19(3):222-225. View abstract.
Freile, M. L., Giannini, F., Pucci, G., Sturniolo, A., Rodero, L., Pucci, O., Balzareti, V., and Enriz, R. D. Antimicrobial activity of aqueous extracts and of berberine isolated from Berberis heterophylla. Fitoterapia 2003;74(7-8):702-705. View abstract.
Fukuda, K., Hibiya, Y., Mutoh, M., Koshiji, M., Akao, S., and Fujiwara, H. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol. 1999;66(2):227-233. View abstract.
Gacche, RN and Dhole, NA. [Antioxidant and possible anti-inflammatory potential of selected medicinal plants prescribed in the indian traditional system of medicine]. Pharmaceutical Biology (Netherlands) 2006;44:389-395.
Gao, C. R., Zhang, J. Q., and Huang, Q. L. [Experimental study on berberin raised insulin sensitivity in insulin resistance rat models]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1997;17(3):162-164. View abstract.
Ghosh AK, Bhattacharyya FK, and Ghosh DK. Leishmania donovani: amastigote inhibition and mode of action of berberine. Experimental Parasitology 1985;60:404-413.
Ghosh, A. K., Rakshit, M. M., and Ghosh, D. K. Effect of berberine chloride on Leishmania donovani. Indian J Med.Res. 1983;78:407-416. View abstract.
Gilani, A. H. and Janbaz, K. H. Prevention of acetaminophen-induced liver damage by Berberis aristata leaves. Biochem Soc Trans. 1992;20(4):347S. View abstract.
Gupta, S. K., Agarwal, R., Srivastava, S., Agarwal, P., Agrawal, S. S., Saxena, R., and Galpalli, N. The anti-inflammatory effects of Curcuma longa and Berberis aristata in endotoxin-induced uveitis in rabbits. Invest Ophthalmol.Vis.Sci. 2008;49(9):4036-4040. View abstract.
Haghighi M, Khalvat A, Toliat T, and Jallaei S. Comparing the effects of ginger (Zingiber officinale) extract and ibuprofen on patients with osteoarthritis. Arch Iranian Med 2011;8(4):267-271.
Haginawa J and Harada M. Pharmacologic studies on crude drugs. V. Comparison of berberine type-alkaloid-containing plants on their components and several pharmacological actions. Yakugaku Zasshi 1962;82:726.
Haisong J, Xiaojie L, Baolu Z, and et al. Scavenging effect of berbamine on active oxygen radicals in phorbol ester-stimulated human polymorphonuclear leukocytes. Biochemical Pharmacology 1990;39(11):1673.
Hajnicka, V., Kost'alova, D., Svecova, D., Sochorova, R., Fuchsberger, N., and Toth, J. Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1. Planta Med 2002;68(3):266-268. View abstract.
Hashmi, K. and Hafiz, A. In vivo antibacterial activity of Berberis asiatica. J Pak Med Assoc 1986;36(1):5-7. View abstract.
Hoshi, A., Ikekawa, T., Ikeda, Y., Shirakawa, S., and Iigo, M. Antitumor activity of berberrubine derivatives. Gann 1976;67(2):321-325. View abstract.
Huang W, Zhang Z, and Xu Y. Study of the effects and mechanisms of berberine on slow-response action potentials. Journal of Electrocardiology 1990;23(3):231-234.
Huang, W. [Ventricular tachyarrhythmias treated with berberine]. Zhonghua Xin.Xue.Guan.Bing.Za Zhi. 1990;18(3):155-6, 190. View abstract.
Huang, W. M., Wu, Z. D., and Gan, Y. Q. [Effects of berberine on ischemic ventricular arrhythmia]. Zhonghua Xin.Xue.Guan.Bing.Za Zhi. 1989;17(5):300-1, 319. View abstract.
Hui, K. K., Yu, J. L., Chan, W. F., and Tse, E. Interaction of berberine with human platelet alpha 2 adrenoceptors. Life Sci. 1991;49(4):315-324. View abstract.
Imanshahidi, M. and Hosseinzadeh, H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother.Res 2008;22(8):999-1012. View abstract.
Ivanovska, N., Philipov, S., and Hristova, M. Influence of berberine on T-cell mediated immunity. Immunopharmacol.Immunotoxicol. 1999;21(4):771-786. View abstract.
Jaswal, S., Mehta, H. C., Sood, A. K., and Kaur, J. Antioxidant status in rheumatoid arthritis and role of antioxidant therapy. Clin Chim Acta 2003;338(1-2):123-129. View abstract.
Joshi, P. V., Shirkhedkar, A. A., Prakash, K., and Maheshwari, V. L. Antidiarrheal activity, chemical and toxicity profile of Berberis aristata. Pharm Biol 2011;49(1):94-100. View abstract.
Kaneda Y, Tanaka T, and Saw T. Effects of berberine, a plant alkaloid, on the growth of anaerobic protozoa in axenic culture. Tokai J Exp Clin Med 1990;15(6):417-423.
Khattak, S. G., Gilani, S. N., and Ikram, M. Antipyretic studies on some indigenous Pakistani medicinal plants. J Ethnopharmacol. 1985;14(1):45-51. View abstract.
Khin, Maung U. and Nwe, Nwe Wai. Effect of berberine on enterotoxin-induced intestinal fluid accumulation in rats. J Diarrhoeal Dis Res 1992;10(4):201-204. View abstract.
Kost'alova, D., Kardosova, A., and Hajnicka, V. Effect of Mahonia aquifolium stem bark crude extract and one of its polysaccharide components on production of IL-8. Fitoterapia 2001;72(7):802-806. View abstract.
Kostalova, D., Bukovsky, M., Koscova, H., and Kardosova, A. [Anticomplement activity of Mahonia aquifolium bisbenzylisoquinoline alkaloids and berberine extract]. Ceska.Slov.Farm 2001;50(6):286-289. View abstract.
Krishnan, P. and Bastow, K. F. The 9-position in berberine analogs is an important determinant of DNA topoisomerase II inhibition. Anticancer Drug Des 2000;15(4):255-264. View abstract.
Krol R, Zalewski A, and Maroko PR. Beneficial effects of berberine, a new positive inotropic agent, on digitalis-induced ventricular arrhythmias. Circulation 1982;66(suppl 2):56.
Krol R, Zalewski A, Cheung W, and et al. Additive effects of berberine and ouabain on myocardial contractility. Clin Res 1982;30(3):673A.
Ksiezycka E, Cheung W, and Maroko PR. Antiarrhythmic effects of berberine on aconitine-induced ventricular and supraventricular arrhythmias. Clinical Research 1983;31(2):197A.
Kulkarni, S. K. and Dhir, A. On the mechanism of antidepressant-like action of berberine chloride. Eur J Pharmacol 7-28-2008;589(1-3):163-172. View abstract.
Kulkarni, S. K. and Dhir, A. Possible involvement of L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride. Eur J Pharmacol 8-13-2007;569(1-2):77-83. View abstract.
Kulkarni, S. K., Dandiya, P. C., and Varandani, N. L. Pharmacological investigations of berberine sulphate. Jpn.J Pharmacol. 1972;22(1):11-16. View abstract.
Kumazawa Y, Itagaki A, Fukumoto M, and et al. Activation of peritoneal macrophages by berberine-type alkaloids in terms of induction of cytostatic activity. Int J Immunopharmac 1984;6(6):587-592.
Kuo CL, Chou CC, and Yung BY. Berberine complexes with DNA in the berberine-induced apoptosis in human leukemic HL-60 cells. Cancer Letters 1995;93:193-200.
Lau, C. W., Yao, X. Q., Chen, Z. Y., Ko, W. H., and Huang, Y. Cardiovascular actions of berberine. Cardiovasc Drug Rev 2001;19(3):234-244. View abstract.
Lee, H. Y., He, X., and Ahn, J. Enhancement of antimicrobial and antimutagenic activities of Korean barberry (Berberis koreana Palib.) by the combined process of high-pressure extraction with probiotic fermentation. J Sci Food Agric 2010;90(14):2399-2404. View abstract.
Leitner, J., Hofbauer, F., and Ackerl, M. [Poisoning with a podophyllin-containing wart-treating tincture]. Dtsch.Med Wochenschr. 7-12-2002;127(28-29):1516-1520. View abstract.
Lev, E. [Some evidence for the use of doctrine of signatures in the land of Israel and its environs during the Middle Ages]. Harefuah 2002;141(7):651-5, 664. View abstract.
Lewin NA, Howland MA, and Goldfrank LR. Herbal Preparations. Goldfrank's Toxicological Emergencies. Norwalk, CT: Appleton & Lange;1996.
Li, H., Miyahara, T., Tezuka, Y., Namba, T., Suzuki, T., Dowaki, R., Watanabe, M., Nemoto, N., Tonami, S., Seto, H., and Kadota, S. The effect of kampo formulae on bone resorption in vitro and in vivo. II. Detailed study of berberine. Biol Pharm Bull 1999;22(4):391-396. View abstract.
Li, S. Y., Ling, L. H., Teh, B. S., Seow, W. K., and Thong, Y. H. Anti-inflammatory and immunosuppressive properties of the bis- benzylisoquinolines: in vitro comparisons of tetrandrine and berbamine. Int J Immunopharmacol. 1989;11(4):395-401. View abstract.
Li, T. K., Bathory, E., LaVoie, E. J., Srinivasan, A. R., Olson, W. K., Sauers, R. R., Liu, L. F., and Pilch, D. S. Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions. Biochemistry 6-20-2000;39(24):7107-7116. View abstract.
Liu CX, Xiao PG, and Liu GS. Studies on plant resources, pharmacology and clinical treatment with berbamine. Phytotherapy Research 1991;5:228-230.
Lubell, J. D., Brand, M. H., Lehrer, J. M., and Holsinger, K. E. Detecting the influence of ornamental Berberis thunbergii var. atropurpurea in invasive populations of Berberis thunbergii (Berberidaceae) using AFLP1. Am J Bot 2008;95(6):700-705. View abstract.
Luo C, Lin X, Li W, and et al. Study on the immunosuppressive effects of berbamine and its mechanism. Phytotherapy Research 1997;11:585-587.
Luo, C. N., Lin, X., Li, W. K., Pu, F., Wang, L. W., Xie, S. S., and Xiao, P. G. Effect of berbamine on T-cell mediated immunity and the prevention of rejection on skin transplants in mice. J Ethnopharmacol. 1998;59(3):211-215. View abstract.
Mahajan VM, Sharma A, and Rattan A. Antimycotic activity of berberine sulphate: an alkaloid from an Indian medicinal herb. Sabouraudia 1982;20:79-81.
Makarem A, Khalili N, and Asodeh R. [Efficacy of barberry aqueous extracts dental gel on control of plaque and gingivitis.]. Acta Medica Iranica 2007;45(2):91-94.
Marin-Neto, J. A., Maciel, B. C., Secches, A. L., and Gallo, Junior L. Cardiovascular effects of berberine in patients with severe congestive heart failure. Clin.Cardiol. 1988;11(4):253-260. View abstract.
Mehta, K., Gala, J., Bhasale, S., Naik, S., Modak, M., Thakur, H., Deo, N., and Miller, M. J. Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. BMC.Complement Altern Med 2007;7:34. View abstract.
Miller, M. J., Mehta, K., Kunte, S., Raut, V., Gala, J., Dhumale, R., Shukla, A., Tupalli, H., Parikh, H., Bobrowski, P., and Chaudhary, J. Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. J Inflamm.(Lond) 10-21-2005;2:11. View abstract.
Minaiyan, M, Ghannadi, A, Mahzouni, P, and Jaffari-Shirazi, E. [Comparative Study of Berberis vulgaris Fruit Extract and Berberine Chloride Effects on Acetic Acid-Induced Colitis in Rats]. Iranian Journal of Pharmaceutical Research 2011;10:97-104.
Misik, V., Bezakova, L., Malekova, L., and Kostalova, D. Lipoxygenase inhibition and antioxidant properties of protoberberine and aporphine alkaloids isolated from Mahonia aquifolium. Planta Med 1995;61(4):372-373. View abstract.
Mitani, N., Murakami, K., Yamaura, T., Ikeda, T., and Saiki, I. Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma. Cancer Lett. 4-10-2001;165(1):35-42. View abstract.
Miura N, Yamamoto M, Ueki T, and et al. Inhibition of thymocyte apoptosis by berberine. Biochemical Pharmacology 1997;53:1315-1322.
Mohan, M., Sekhar, G. C., and Mahajan, V. M. Berberine: an indigenous drug in experimental herpetic uveitis. Indian J Ophthalmol. 1983;31(2):65-68. View abstract.
Muller, K., Ziereis, K., and Gawlik, I. The antipsoriatic Mahonia aquifolium and its active constituents; II. Antiproliferative activity against cell growth of human keratinocytes. Planta Med 1995;61(1):74-75. View abstract.
Ni, Y. X. [Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research]. Zhong.Xi.Yi.Jie.He.Za Zhi.- Chinese Journal of Modern Developments in Traditional Medicine 1988;8(12):711-3, 707. View abstract.
Nishino H, Kitagawa K, Fujiki H, and et al. Berberine sulfate inhibits tumor-promoting activity of teleocidin in two-stage carcinogenesis on mouse skin. Oncology 1986;43:131-134.
Ozaki Y, Suzuki H, and Satake M. [Comparative studies on concentration of berberine in plasma after oral administration of Coptidis rhizoma extract, its cultured cells extract, and combined use of these extracts and glycyrrhizae radix extract in rats]. Yakugaku Zasshi 1993;113(1):63-69.
Palasuntheram C, Iyer KS, de Silva LB, and et al. Antibacterial activity of Coscinium fenestratum Colebr against Clostridium tetani. Ind J Med Res 1982;76(Suppl):71-76.
Palmery M, Leone MG, Pimpinella G, and et al. Effects of Hydrastis canadensis L. and the two major alkaloids berberine and hydrastine on rabbit aorta. Pharmacological Research 1993;27(suppl 1):73-74.
Parsaee, H, Shafel, MN, and Boskabady, MH. [Effects of hydro-ethanolic extract of berberis vulgaris fruit on rabbit isolated heart.]. DARU, Journal of Faculty of Pharmacy, Tehran University of Medical Sciences (Iran) 2006;14:208-213.
Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. View abstract.
Pozniakovskii, V. M., Golub, O. V., Popova, D. G., and Kovalevskaia, I. N. [The use of barberry berries in human nutrition]. Vopr.Pitan. 2003;72(4):46-49. View abstract.
Proudman, S. M., Keen, H. I., Stamp, L. K., Lee, A. T., Goldblatt, F., Ayres, O. C., Rischmueller, M., James, M. J., Hill, C. L., Caughey, G. E., and Cleland, L. G. Response-driven combination therapy with conventional disease-modifying antirheumatic drugs can achieve high response rates in early rheumatoid arthritis with minimal glucocorticoid and nonsteroidal anti-inflammatory drug use. Semin.Arthritis Rheum 2007;37(2):99-111. View abstract.
Remans, P. H., Sont, J. K., Wagenaar, L. W., Wouters-Wesseling, W., Zuijderduin, W. M., Jongma, A., Breedveld, F. C., and Van Laar, J. M. Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. Eur J Clin Nutr 2004;58(6):839-845. View abstract.
Ren, Y., Lu, L., Guo, T. B., Qiu, J., Yang, Y., Liu, A., and Zhang, J. Z. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis. J Immunol. 7-15-2008;181(2):1491-1498. View abstract.
Ribeiro LG, Bowker BL, Maroko PR, and et al. Beneficial effects of berberine on early mortality after experimental coronary artery occlusion in rats. Circulation 1982;66:II-56.
Rodov, V., Vinokur, Y., Gogia, N., and Chkhikvishvili, I. Hydrophilic and lipophilic antioxidant capacities of Georgian spices for meat and their possible health implications. Georgian.Med News 2010;(179):61-66. View abstract.
Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Altern.Ther.Health Med. 2010;16(2):32-40. View abstract.
Ryzhikova, M. A., Farkhutdinov, R. R., Sibiriak, S. V., and Zagidullin, ShZ. [The effect of aqueous extracts of hepatotropic medicinal plants on free-radical oxidation processes]. Eksp.Klin.Farmakol. 1999;62(2):36-38. View abstract.
Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
Sabir M, Mahajan VM, Mohapatra LN, and et al. Experimental study of the antitrachoma action of berberine. Indian J Med Res 1976;64(8):1160-1167.
Sack, R. B. and Froehlich, J. L. Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins. Infect Immun. 1982;35(2):471-475. View abstract.
Sanders MM, Liu AA, Li TK, and et al. Selective cytotoxicity of topoisomerase-directed protoberberines against glioblastoma cells. Biochemical Pharmacology 1998;56:1157-1166.
Saxe, T. G. Toxicity of medicinal herbal preparations. Am.Fam.Physician 1987;35(5):135-142. View abstract.
Seery TM and Bieter RN. A contribution to the pharmacology of berberine. J Pharmacol Exp Ther 1940;69:64-67.
Seow WK, Ferrante A, Summors A, and et al. Comparative effects of tetrandrine and berbamine on production of the inflammatory cytokines interleukin-1 and tumor necrosis factor. Life Sciences 1992;50(8):pl-53-pl-58.
Shaffer, J. E. Inotropic and chronotropic activity of berberine on isolated guinea pig atria. J Cardiovasc Pharmacol 1985;7(2):307-315. View abstract.
Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. View abstract.
Sharda DC. Berberine in the treatment of diarrhoea of infancy and childhood. J Indian M A 1970;54(1):22-24.
Sharma, R. S., Mishra, V., Singh, R., Seth, N., and Babu, C. R. Antifungal activity of some Himalayan medicinal plants and cultivated ornamental species. Fitoterapia 2008;79(7-8):589-591. View abstract.
Sheng WD, Jiddawi MS, Hong XQ, and et al. Treatment of chloroquine-resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazole. East African Medical Journal 1997;74(5):283-284.
Singh, J. and Kakkar, P. Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats. J Ethnopharmacol. 5-4-2009;123(1):22-26. View abstract.
Singh, M., Srivastava, S., and Rawat, A. K. Antimicrobial activities of Indian Berberis species. Fitoterapia 2007;78(7-8):574-576. View abstract.
Srivastava, S. K., Rai, V., Srivastava, M., Rawat, A. K., and Mehrotra, S. Estimation of heavy metals in different berberis species and its market samples. Environ Monit.Assess. 2006;116(1-3):315-320. View abstract.
Subbaiah TV and Amin AH. Effect of berberine sulphate on Entamoeba histolytica. Nature 1967;215(100):527-528.
Sun D, Courtney HS, and Beachey EH. Berberine sulfate blocks adherence of Streptococcus pyogenes to epithelial cells, fibronectin, and hexadecane. Antimicrobial Agents and Chemotherapy 1988;32(9):1370-1374.
Sundrarjun, T., Komindr, S., Archararit, N., Dahlan, W., Puchaiwatananon, O., Angthararak, S., Udomsuppayakul, U., and Chuncharunee, S. Effects of n-3 fatty acids on serum interleukin-6, tumour necrosis factor-alpha and soluble tumour necrosis factor receptor p55 in active rheumatoid arthritis. J Int Med Res 2004;32(5):443-454. View abstract.
Supek Z and Tomic D. Farmakološko-kemijsko istrazivanje zutike (
Swabb, E. A., Tai, Y. H., and Jordan, L. Reversal of cholera toxin-induced secretion in rat ileum by luminal berberine. Am J Physiol 1981;241(3):G248-G252. View abstract.
Tai YH, Feser JF, Marnane WG, and et al. Antisecretory effects of berberine in rat ileum. Am J Physiol 1981;241:G253-G258.
Taylor CT and Baird AW. Berberine inhibition of electrogenic ion transport in rat colon. Br J Pharmacology 1995;116:2667-2672.
Teh BS, Seow WK, Li SY, and et al. Inhibition of prostaglandin and leukotriene generation by the plant alkaloids tetrandrine and berbamine. Int J Immnopharmac 1990;12(3):321-326.
Tomosaka, H., Chin, Y. W., Salim, A. A., Keller, W. J., Chai, H., and Kinghorn, A. D. Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry). Phytother.Res 2008;22(7):979-981. View abstract.
Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
Verma RL. Ind Med Gaz 1933;68:122.
Vik-Mo H, Faria DB, Cheung WM, and et al. Beneficial effects of berberine on left ventricular function in dogs with heart failure. Clinical Research 1983;31(2):224a.
Volker, D., Fitzgerald, P., Major, G., and Garg, M. Efficacy of fish oil concentrate in the treatment of rheumatoid arthritis. J Rheumatol 2000;27(10):2343-2346. View abstract.
Vollekova, A., Kostalova, D., and Sochorova, R. Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp. Folia Microbiol.(Praha) 2001;46(2):107-111. View abstract.
Wang YX, Yao XJ, and Tan YH. Effects of berberine on delayed afterdepolarizations in ventricular muscles in vitro and in vivo. Journal of Cardiovascular Pharmacology 1994;23(5):716-722.
Wang, G. Y., Lv, Q. H., Dong, Q., Xu, R. Z., and Dong, Q. H. Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice. J Asian Nat Prod Res 2009;11(3):219-228. View abstract.
Wong, C. W., Seow, W. K., O'Callaghan, J. W., and Thong, Y. H. Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor. Agents Actions 1992;36(1-2):112-118. View abstract.
Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102. View abstract.
Xuan, B., Wang, W., and Li, D. X. Inhibitory effect of tetrahydroberberine on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1994;15(2):133-135. View abstract.
Yogesh, H. S., Chandrashekhar, V. M., Katti, H. R., Ganapaty, S., Raghavendra, H. L., Gowda, G. K., and Goplakhrishna, B. Anti-osteoporotic activity of aqueous-methanol extract of Berberis aristata in ovariectomized rats. J Ethnopharmacol. 3-24-2011;134(2):334-338. View abstract.
Yuan, J., Shen, X. Z., and Zhu, X. S. [Effect of berberine on transit time of human small intestine]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1994;14(12):718-720. View abstract.
Zalewski A, Krol R, and Maroko PR. Berberine, a new inotropic agent - distinction between its cardiac and peripheral responses. Clin Res 1983;31(2):227A.
Zhang, C. M., Gao, L., Zheng, Y. J., and Yang, H. T. Berbamine increases myocardial contractility via a Ca2+-independent mechanism. J Cardiovasc.Pharmacol 2011;58(1):40-48. View abstract.
Zhang, M. F. and Shen, Y. Q. [Antidiarrheal and anti-inflammatory effects of berberine]. Zhongguo Yao Li Xue.Bao. 1989;10(2):174-176. View abstract.
Zhang, R. X., Dougherty, D. V., and Rosenblum, M. L. Laboratory studies of berberine used alone and in combination with 1,3-bis(2-chloroethyl)-1-nitrosourea to treat malignant brain tumors. Chin Med.J (Engl.) 1990;103(8):658-665. View abstract.
Zhou, J., Xuan, B., and Li, D. X. Effects of tetrahydroberberine on ischemic and reperfused myocardium in rats. Zhongguo Yao Li Xue.Bao. 1993;14(2):130-133. View abstract.
Zhu B and Ahrens FA. Effect of berberine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in jejunum of pigs. Am J Vet Res 1982;43(9):1594-1598.
Zhu, B. and Ahrens, F. Antisecretory effects of berberine with morphine, clonidine, L- phenylephrine, yohimbine or neostigmine in pig jejunum. Eur J Pharmacol 12-9-1983;96(1-2):11-19. View abstract.
Zovko, Koncic M., Kremer, D., Karlovic, K., and Kosalec, I. Evaluation of antioxidant activities and phenolic content of Berberis vulgaris L. and Berberis croatica Horvat. Food Chem Toxicol. 2010;48(8-9):2176-2180. View abstract.
Altman RD, Marcussen KC. Effects of ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum 2001;44:2531-38. View abstract.
Amin AH, Subbaiah TV, Abbasi KM. Berberine sulfate: antimicrobial activity, bioassay, and mode of action. Can J Microbiol 1969;15:1067-76. View abstract.
Ang ES, Lee ST, Gan CS, et al. Evaluating the role of alternative therapy in burn wound management: randomized trial comparing moist exposed burn ointment with conventional methods in the management of patients with second-degree burns. MedGenMed 2001;3:3. View abstract.
Anis KV, Rajeshkumar NV, Kuttan R. Inhibition of chemical carcinogenesis by berberine in rats and mice. J Pharm Pharmacol 2001;53:763-8. . View abstract.
Bhide MB, Chavan SR, Dutta NK. Absorption, distribution and excretion of berberine. Indian J Med Res 1969;57:2128-31. View abstract.
Bliddal H, Rosetzsky A, Schlichting P, et al. A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage 2000;8:9-12. View abstract.
Brand C, Snaddon J, Bailey M, Cicuttini F. Vitamin E is ineffective for symptomatic relief of knee osteoarthritis: a six month double blind, randomised, placebo controlled study. Ann Rheum Dis 2001;60:946-9. View abstract.
Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. View abstract.
Edmonds SE, Winyard PG, Guo R, et al. Putative analgesic activity of repeated oral doses of vitamin E in the treatment of rheumatoid arthritis. Results of a prospective placebo controlled double blind trial. Ann Rheum Dis 1997;56:649-55. View abstract.
Fatehi M, Saleh TM, Fatehi-Hassanabad Z, et al. A pharmacological study on Berberis vulgaris fruit extract. J Ethnopharmacol 2005;102:46-52. View abstract.
Fukuda K, Hibiya Y, Mutoh M, et al. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 1999;66:227-33. View abstract.
Gupte S. Use of berberine in treatment of giardiasis. Am J Dis Child 1975;129:866. View abstract.
Hsiang CY, Wu SL, Cheng SE, Ho TY. Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. J Biomed Sci 2005;12:791-801. View abstract.
Ivanovska N, Philipov S. Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. Int J Immunopharmacol 1996;18:553-61. View abstract.
Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. View abstract.
Kaneda Y, Torii M, Tanaka T, Aikawa M. In vitro effects of berberine sulphate on the growth and structure of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Ann Trop Med Parasitol 1991;85:417-25. View abstract.
Khosla PG, Neeraj VI, Gupta SK, et al. Berberine, a potential drug for trachoma. Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique 1992;69:147-65. View abstract.
Kim SH, Shin DS, Oh MN, et al. Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. Biosci Biotechnol Biochem 2004;68:421-4.. View abstract.
Li B, Shang JC, Zhou QX. [Study of total alkaloids from rhizoma coptis chinensis on experimental gastric ulcers]. Chin J Integr Med 2005;11:217-21. View abstract.
Mur E, Hartig F, Eibl G, Schirmer M. Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. J Rheumatol 2002;29:678-81. View abstract.
Park KS, Kang KC, Kim JH, et al. Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans. J Antimicrob Chemother 1999;43:667-74. View abstract.
Piscoya J, Rodriguez Z, Bustamante SA, et al. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res 2001;50:442-448. View abstract.
Rehman J, Dillow JM, Carter SM, et al. Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis. Immunol Lett 1999;68:391-5. View abstract.
Scazzocchio F, Corneta MF, Tomassini L, Palmery M. Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. Planta Med 2001;67:561-4. View abstract.
Shamsa F, Ahmadiani A, Khosrokhavar R. Antihistaminic and anticholinergic activity of barberry fruit (Berberis vulgaris) in the guinea-pig ileum. J Ethnopharmacol 1999;64:161-6. View abstract.
Sun D, Courtney HS, Beachey EH. Berberine sulfate blocks adherence of Streptococcus pyogenes to epithelial cells, fibronectin, and hexadecane. Antimicrob Agents Chemother 1988;32:1370-4. View abstract.
Tsai PL, Tsai TH. Hepatobiliary excretion of berberine. Drug Metab Dispos 2004;32:405-12. . View abstract.
Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage 2003;11:783-9. View abstract.
Wluka AE, Stuckey S, Brand C, Cicuttini FM. Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: A 2 year double blind randomized placebo controlled study. J Rheumatol 2002;29:2585-91. View abstract.
Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. View abstract.
Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2003;92:173-6. View abstract.