Bugleweed

Last Editorial Review: 6/11/2021
Other Name(s):

Ajuga, Archangle, Ashangee, Chanvre d'Eau, Green Wolf's Foot, Gypsy Weed, Gypsywort, Hoarhound, Lycope, Lycope d'Amérique, Lycope d'Europe, Lycope de Virginie, Lycopi Herba, Lycopus americanus, Lycopus europaeus, Lycopus Europea, Lycopus virginicus, Menta de Lobo, Patte-de-Loup, Paul's Betony, Sweet Bugle, Water Bugle, Water Hoarhound, Water Horehound, Virginia Water Horehound, Wolfstrapp.

Overview

Bugleweed is a plant. People use the parts that grow above the ground for medicine.

Bugleweed is used to lower high levels of thyroid hormones (hyperthyroidism). It is also used to treat premenstrual syndrome; breast pain; nervousness; trouble sleeping (insomnia); and bleeding, especially nosebleeds and heavy bleeding during menstruation.

How does it work?

Bugleweed might reduce the body's production of thyroid hormone. Bugleweed also seems to reduce the release of the hormone prolactin, which might help relieve breast pain.

SLIDESHOW

Vitamin D Deficiency: How Much Vitamin D Is Enough? See Slideshow

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate the effectiveness of bugleweed for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

Bugleweed is POSSIBLY SAFE for most people when taken by mouth, but thyroid disease should not be self-treated due to possible complications. Long-term use of bugleweed can cause an enlarged thyroid gland. Discontinuing bugleweed abruptly can result in high levels of thyroid and prolactin, which might cause physical symptoms.

QUESTION

Next to red peppers, you can get the most vitamin C from ________________. See Answer

Special Precautions & Warnings

Pregnancy and breast-feeding: It's LIKELY UNSAFE to take bugleweed by mouth during pregnancy because it might affect hormones. It's also LIKELY UNSAFE to take bugleweed by mouth while breast-feeding. It can affect milk production.

Diabetes: Bugleweed might lower blood sugar. If you have diabetes, use bugleweed cautiously, watch for symptoms of low blood sugar, and check your blood sugar carefully. The dose of your diabetes medications may need to be adjusted.

Surgery: Bugleweed might affect blood sugar levels. There is some concern that it might interfere with blood sugar control during and after surgery. Stop using bugleweed at least 2 weeks before a scheduled surgery.

Enlarged thyroid or poorly functioning thyroid (thyroid hypofunction): Don't use bugleweed if you have one of these conditions or are receiving thyroid treatments.

Interactions


Medications for diabetes (Antidiabetes drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Bugleweed might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking bugleweed along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.


Thyroid hormoneInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Taking bugleweed might decrease how well thyroid hormone pills work. Don't take bugleweed if you take thyroid pills.

Dosing

The appropriate dose of bugleweed depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bugleweed. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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References

[Complementary medicine. Calming lycopus]. Schweiz.Rundsch.Med Prax. 12-22-2004;93(51-52):2161. View abstract.

Auf'mkolk, M., Ingbar, J. C., Kubota, K., Amir, S. M., and Ingbar, S. H. Extracts and auto-oxidized constituents of certain plants inhibit the receptor-binding and the biological activity of Graves' immunoglobulins. Endocrinology 1985;116(5):1687-1693. View abstract.

Auf'mkolk, M., Kohrle, J., Gumbinger, H., Winterhoff, H., and Hesch, R. D. Antihormonal effects of plant extracts: iodothyronine deiodinase of rat liver is inhibited by extracts and secondary metabolites of plants. Horm.Metab Res 1984;16(4):188-192. View abstract.

Bucar, F. and Kartnig, T. Flavone Glucuronides of Lycopus virginicus. Planta Med 1995;61(4):378-380. View abstract.

HOERHAMMER, L., WAGNER, H., and SCHILCHER, H. [On the knowledge of the constituents of Lycopus europaeus. 1. On the constituents of medicinal plants with hormone and antihormone-like action.]. Arzneimittelforschung. 1962;12:1-7. View abstract.

Hussein, A. A. and Rodriguez, B. Isopimarane diterpenoids from Lycopus europaeus. J Nat.Prod. 2000;63(3):419-421. View abstract.

Kartnig, T., Bucar, F., and Neuhold, S. Flavonoids from the Aboveground Parts of Lycopus virginicus. Planta Med 1993;59(6):563-564. View abstract.

Rompel, A., Fischer, H., Meiwes, D., Buldt-Karentzopoulos, K., Magrini, A., Eicken, C., Gerdemann, C., and Krebs, B. Substrate specificity of catechol oxidase from Lycopus europaeus and characterization of the bioproducts of enzymic caffeic acid oxidation. FEBS Lett. 2-19-1999;445(1):103-110. View abstract.

Sourgens, H., Winterhoff, H., Gumbinger, H. G., and Kemper, F. H. Antihormonal effects of plant extracts. Planta Med 1982;45(6):78-86. View abstract.

Vonhoff, C., Baumgartner, A., Hegger, M., Korte, B., Biller, A., and Winterhoff, H. Extract of Lycopus europaeus L. reduces cardiac signs of hyperthyroidism in rats. Life Sci 2-2-2006;78(10):1063-1070. View abstract.

Wagner, H., Horhammer, L., and Frank, U. [Lithospermic acid, the antihormonally active principle of Lycopus europaeus L. and Symphytum officinale. 3. Ingredients of medicinal plants with hormonal and antihormonal-like effect]. Arzneimittelforschung 1970;20(5):705-713. View abstract.

Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. View abstract.