Generic Name: alprazolam
Brand Names: Xanax, Xanax XR, Niravam
Drug Class: Anxiolytics, Benzodiazepines
What is alprazolam, and what is it used for?
Alprazolam (Xanax, Xanax XR, Niravam), is an anti-anxiety medication in the benzodiazepine drug family, the same family that includes diazepam (Valium), clonazepam (Klonopin), lorazepam (Ativan), flurazepam (Dalmane), and others.
Alprazolam and other benzodiazepines act by enhancing the effects of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter (a chemical that nerve cells use to communicate with each other) that inhibits activity in the brain. It is believed that excessive activity in the brain may cause anxiety or other psychiatric disorders.
Alprazolam is used for the treatment of anxiety disorders and panic attacks. Anxiety disorders are characterized by:
- Unrealistic worry and apprehension
- Symptoms of restlessness
- Aches
- Trembling
- Shortness of breath
- Smothering sensation
- Palpitations
- Sweating
- Cold clammy hands
- Lightheadedness
- Flushing
- Exaggerated startle responses
- Problems concentrating
- Insomnia
Alprazolam is also used for treating anxiety associated with panic attacks. Panic attacks occur either unexpectedly or in certain situations (for example, driving), and can require higher dosages of alprazolam.
The FDA approved alprazolam in October 1981.
What are the side effects of alprazolam?
The most common side effects of alprazolam taken at lower doses are:
- Drowsiness
- Fatigue
Other side effects include:
- Memory problems
- Speech problems
- Constipation
- Changes in weight
- Addiction (dependency)
- Headache
- Constipation
- Dry mouth
SLIDESHOW
A Visual Guide to Generalized Anxiety Disorder See SlideshowWhat is the dosage for alprazolam?
- The starting dose for treating anxiety is 0.25-0.5 mg 3 to 4 times daily using immediate-release tablets. The dose may be increased every 3-4 days to a maximum dose of 4 mg daily.
- The starting dose for treating panic attacks is 0.5 mg 3 times daily. Doses can be increased every 3-4 days but by no more than 1 mg daily.
- The effective dose for preventing panic attacks may be as high as 10 mg daily for some patients. The starting dose when using extended-release tablets to treat panic disorder is 0.5 mg once daily and the average dose is 3-6 mg once daily.
- Alprazolam may be taken with or without food.
Is alprazolam addictive?
The use of benzodiazepines, including alprazolam, exposes users to the risks of abuse, misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines often (but not always) involve the use of doses greater than the maximum recommended dosage and commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, or death
Withdrawal symptoms of alprazolam
Addiction is more likely to occur at high doses given over prolonged periods. Abrupt discontinuation of alprazolam after prolonged use can lead to symptoms of withdrawal such as:
Seizures can occur in more severe cases of withdrawal. Consequently, patients on alprazolam for extended periods of time should slowly taper the medication under a doctor's supervision rather than abruptly stopping the medication.
What drugs interact with alprazolam?
- Ketoconazole (Nizoral), itraconazole (Sporanox), nefazodone (Serzone), cimetidine (Tagamet), and fluvoxamine (Luvox) increase concentrations in the blood of alprazolam and therefore may increase the side effects of alprazolam.
- Alprazolam interacts with alcohol and medications (for example, barbiturates, and narcotics) that suppress activity in the brain by suppressing activity more and causing sedation.
- Carbamazepine and rifampin reduce the effect of alprazolam by increasing metabolism and elimination of alprazolam in the liver.
Is alprazolam safe to take if I'm pregnant or breastfeeding?
- Benzodiazepines, such as alprazolam, can cause fetal abnormalities and should not be used in pregnancy.
- Alprazolam is excreted in breast milk and it can affect nursing infants. Therefore, women who are should not take alprazolam while breastfeeding.
What else should I know about alprazolam?
Alprazolam is available as:
- Tablets: 0.25, 0.5, 1 and 2 mg.
- Tablets ER (extended release): 0.5, 1, 2 and 3 mg.
- Tablets (Orally disintegrating): 0.25, 0.5, 1 and 2 mg. Solution: 1 mg/ml
Keep alprazolam should be stored at room temperature, 15 C to 30 C (59 F to 86 F).
Alprazolam is available in generic form, and you need a prescription from your doctor or other health-care professional to obtain this drug.
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Summary
Alprazolam is a member of the benzodiazepine family, which are sedatives that cause dose-related depression of the central nervous system. Alprazolam is used for the treatment of anxiety disorders and panic attacks, which cause unrealistic worry and apprehension, restlessness, aches, trembling, shortness of breath, smothering sensation, palpitations, sweating, cold clammy hands, lightheadedness, flushing, exaggerated startle responses, problems concentrating, and insomnia. Side effects of alprazolam may include drowsiness, fatigue, memory problems, speech problems, constipation, changes in weight, addiction (dependency), headache, constipation, and dry mouth. Do not take if pregnant or breastfeeding.
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