- What is dalfampridine, Ampyra, and how does it work (mechanism of action)?
- What brand names are available for dalfampridine, Ampyra?
- Is dalfampridine, Ampyra available as a generic drug?
- Do I need a prescription for dalfampridine, Ampyra?
- What are the side effects of dalfampridine, Ampyra?
- What is the dosage for dalfampridine, Ampyra?
- Which drugs or supplements interact with dalfampridine, Ampyra?
- Is dalfampridine, Ampyra safe to take if I'm pregnant or breastfeeding?
- What else should I know about dalfampridine, Ampyra?
What is dalfampridine, Ampyra, and how does it work (mechanism of action)?
Ampyra is an oral medication used for treating multiple sclerosis (MS). Its exact mechanism of action is unknown, but it is known to block movement of potassium between nerve cells. In animal studies Ampyra increased the conduction of nerve signals. The FDA approved Ampyra in December 1987.
What are the side effects of dalfampridine, Ampyra?
The most common side effect of Ampyra is urinary tract infections.
Other common side effects include:
Serious side effects of Ampyra include:
- seizures, and
- severe allergic reactions (anaphylaxis).
People with a history of seizures should not use Ampyra.
Signs and symptoms of anaphylaxis include difficulty breathing; itching, and swelling of the throat or tongue.
What is the dosage for dalfampridine, Ampyra?
The maximum recommended dose is 10 mg twice daily with or without food about 12 hours apart. Tablets should not be divided, crushed, chewed, or dissolved.
Which drugs or supplements interact with dalfampridine, Ampyra?
Drug interactions have not been identified for Ampyra.
SLIDESHOW
What Is Multiple Sclerosis? MS Symptoms, Causes, Diagnosis See SlideshowIs dalfampridine, Ampyra safe to take if I'm pregnant or breastfeeding?
There are no adequate studies of Ampyra in pregnant women.
It is not known whether Ampyra is excreted in human milk.
Summary
dalfampridine (Ampyra) is a medication prescribed to patients with multiple sclerosis (MS) to improve walking. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking this medication.
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Related Disease Conditions
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Multiple Sclerosis (MS)
Multiple sclerosis or MS is an autoimmune disorder in which brain and spinal cord nerve cells become demyelinated. This damage results in symptoms that may include numbness, weakness, vertigo, paralysis, and involuntary muscle contractions. Different forms of MS can follow variable courses from relatively benign to life-threatening. MS is treated with disease-modifying therapies. Some MS symptoms can be treated with medications.
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Multiple Sclerosis (MS) Symptoms and Treatments
Multiple sclerosis (MS) symptoms vary from person to person and can last for days to months without periods of remission. Symptoms of MS include sexual problems and problems with the bowel, bladder, eyes, muscles, speech, swallowing, brain, and nervous system. The early symptoms and signs of multiple sclerosis usually start between ages 20-40. MS in children, teens, and those over age 40 is rare. Treatment options for multiple sclerosis vary depending on the type and severity of symptoms. Medications may be prescribed to manage MS symptoms.
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Alternative Treatment (CAM) for MS
The term alternative therapy, in general, is used to describe any medical treatment or intervention that has not been scientifically documented or identified as safe or effective for a specific condition. Alternative therapy encompasses a variety of disciplines that range from diet and exercise to mental conditioning to lifestyle changes.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
REFERENCE: FDA Prescribing Information.