What is cryoglobulinemia?
Cryoglobulinemia is a medical condition that is caused by proteins called cryoglobulins, which are present in the blood. Cryoglobulins are abnormal proteins that by definition have the unusual property of precipitating from the serum when it is chilled in the laboratory and then dissolves back into the serum upon rewarming.
What does it mean if you test positive for cryoglobulin?
What conditions are associated with cryoglobulinemia?
Cryoglobulins in the blood (cryoglobulinemia) can cause a variety of problems throughout the body. These include complications resulting from abnormal "thickness" of the blood (such as stroke or blood clots in the eyes leading to blindness) and inflammation of blood vessels, referred to as vasculitis. Vasculitis of arteries can result in blockage of blood flow, leading to damage to the organ(s) supplied by the affected blood vessels, such as in the skin, kidneys, or elsewhere. It can also cause bleeding when the blood vessels leak.
What is essential mixed cryoglobulinemia?
When the cryoglobulin proteins are a mixture of various antibody types, and forming for unknown reasons (essential), the condition is referred to as essential mixed cryoglobulinemia.
Essential mixed cryoglobulinemia is characterized by joint pains and swelling (arthritis), enlargement of the spleen, skin vasculitis with purplish patches, and nerve and kidney disease. This can lead to recurrent pain in the abdomen, heart attack, and bleeding in the lungs. Weight loss can occur as well as poor appetite.
Essential mixed cryoglobulinemia is sometimes associated with hepatitis C virus infection.
What is the treatment for cryoglobulinemia?
Essential mixed cryoglobulinemia is treated with combinations of medications which reduce inflammation and suppress the immune system. Medications used include nonsteroid antiinflammatory drugs (ibuprofen, aspirin, and others), steroids (prednisone, prednisolone), cyclophosphamide (Cytoxan), chlorambucil (Leukeran), and azathioprine (Imuran). Plasmapheresis (hemapheresis), a procedure whereby the blood's serum is filtered to remove the cryoglobulins, is also performed for severe symptoms.
Studies have demonstrated some benefit of using interferon-alpha for those patients with evidence of hepatitis C virus, particularly those with mild disease or in those with remission of manifestations after immune suppression treatment.
What is the prognosis for cryoglobulinemia?
The prognosis and natural history of the illness is not predictable. Kidney damage can be serious and some reports state that permanent failure of the kidney occurs in approximately 10% of patients. Death can occur, usually from serious heart disease, infection, or brain hemorrhage.
SLIDESHOW
What's a Virus? Viral Infection Types, Symptoms, Treatment See SlideshowREFERENCES:
Fervenza, Fernando C., MD, PhD, et al. "Clinical manifestations and diagnosis of the mixed cryoglobulinemia syndrome (essential mixed cryoglobulinemia)." UptoDate. Updated Jan 7, 2016.
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aspirin
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Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and gout.azathioprine (Azasan)
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Apheresis (Hemapheresis, Pheresis)
Apheresis (hemapheresis, pheresis) is a process of removing a specific component from the blood of a donor or patient that contains disease-provoking elements. Forms of apheresis include:- plasmapheresis,
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Hepatitis C (HCV, Hep C)
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Kidney (Renal) Failure
Kidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss, dehydration, or medication. Some of the renal causes of kidney failure include sepsis, medications, rhabdomyolysis, multiple myeloma, and acute glomerulonephritis.
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prednisolone (Orapred, Pediapred)
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Skin Biopsy
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Stroke
A stroke is an interruption of the blood supply to part of the brain caused by either a blood clot (ischemic) or bleeding (hemorrhagic). Symptoms of a stroke may include weakness, numbness, double vision or vision loss, confusion, vertigo, difficulty speaking, or understanding speech. A physical exam, imaging tests, neurological exam, and blood tests may be used to diagnose a stroke. Treatment may include administration of clot-busting drugs, supportive care, and in some instances, neurosurgery. The risk of stroke can be reduced by controlling high blood pressure, high cholesterol, diabetes, and stopping smoking.
Vasculitis
Vasculitis (arteritis, angiitis) is a general term for a group of uncommon diseases which feature inflammation of the blood vessels. Each form of vasculitis has its own characteristic pattern of symptoms. The diagnosis of vasculitis is definitively established after a biopsy of involved tissue demonstrates the pattern of blood vessel inflammation. Treatment is directed toward decreasing the inflammation of the arteries and improving the function of affected organs.